Kidney Disease Info, Data, and potential treatments

[Diggie's Friend]

https://www.merckvetmanual.com/all-o...-Rats_v3230138

Kidney and Urinary Disorders of Rats

Chronic progressive nephrosis (glomerulonephrosis) is a common disease of older rats. It involves inflammation of the blood vessels in the kidney. The disease and its severity are influenced by the rat’s sex and hereditary background and by dietary factors such as protein content and total calorie consumption. The disease occurs earlier and is more severe in male rats than in female rats. Affected rats are lethargic and lose weight, and they may have increased thirst and urination

Even with, "Late Stage" Kidney failure in rats, kidney function was improved with oral Calcium citrate. Although other calcium supplement forms were also tested, including Calcium carbonate; they were not found to improve kidney function.

https://vetspace.2ndchance.info/chro...-your-pet-rat/

Diabetes caused by both excessive protein (phosphorus), fat (lipids), and sugar (triglycerides), resulting in insulin resistance, which promote kidney disease, which results in high blood pressure. In research study of these same disorders in rats, oral supplementation of Quercetin. Quercetin can also improve high blood pressure with this same condition. High blood pressure is associated with heart attack, stroke.

In conclusion, our results indicate that quercetin reverses the increase in blood pressure, providing an improved clinical condition in an animal model. This was evidenced by the improvements in the lipid profile and increase in insulin sensitivity through the activation of the initial steps of the insulin signaling cascade in adipose tissue, followed by a protective mechanism against the action and secretion of pancreatic islets., in rats.

Kidney infection can be due to the regular consumption of foods higher in oxalic acid, and or being too acidic from an unhealthy imbalance in the (Ca:P) ratio of the total diet, not just the block diet alone. With commercial rodent block diets being closer than (2:1) (Ca:P) the recipe for disaster is set up when a whole foods component is added to the diet that is lower than equal to that of the block diet itself. Figuratively speaking, this like skating on thin ice and finding that the ice has gotten so thin that it eventually gives way.

[Diggie's Friend]

(Chronic Progressive Nephropathy) CKD, as the name implies, is not an acute disease that doesn't just suddenly occur overnight in old age, but progressively develops over the lifespan of the animal.

The most effective way is to slow up the progressive damage of the kidneys that naturally occurs over the lifetime of an animal. This supported by progressively adjusting down the portion of the block diet that contains the highest protein in the diet, that contains the highest phosphorus in the diet and at the same time, adding back the Calcium Citrate, that form that improves kidney function, vs. C. carbonate that was not found to this in rats, to at least equal that which calcium is lowered in the diet by the reduction of the protein in the block diet. With this, the kidneys don't have to work as hard to filter out phosphorus so that toxins over the lifespan of the squirrel. By this means, wear and tear on the kidneys is reduced in the same time frame over the life of the animal; not by first adjusting the Ca:P ratio of the diet past middle age. This prophylactic approach lends significant potential to extend kidneys function, and so likewise to potentially extend the life.

A (2:1) Ca:P ratio up to a bit above (3:1) was found to support good calcium bone density in adult rats. Starting with the lower end of the health ratio juveniles, and progressively raising this ratio as the squirrel ages by lowering the phosphorus in the diet to (2.8:1) up to (3:1) a higher ratio also found in adult rats that support good bone density.

This veterinarian researcher says older rats can do well on half the amount of protein daily (14%).

https://www.2ndchance.info/ratkidney.htm

The technical progression of (CKD) is described in much technical detail on this page

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The goal is to keep the phosphorus level from getting out of control in the first place. If this is not possible, the goal is to get the phosphorus level back under control and keep it there.

Respiratory infections are noted amongst other symptoms that may be seen with kidney failure. Yet focusing alone on overcoming this and other issues associated with kidney failure isn't as effective as taking a prophylactical approach towards extending the function of the kidneys.

As noted on Ratguide.com, and on the Merck Veterinary Manual online page. Another thing what has been found key in extending the long-term function of the kidneys is including soil based probiotic and prebiotic for squirrels on a whole foods diet. Pet Flora by Vitality Science prebiotic like the probiotic, also counters bad bacteria, whereas sugar based probiotics common to acidophilus formulas, promotes the growth of both bad and good forms of gut flora. Don't let the label put you off, as it isn't just for dogs and cats, but for smaller mammals including wild species of rodents, as the company has confirmed, not containing additives and flavors as most sources do, but a highly diverse complement of various forms of good intestinal bacteria, noted by experts to be the most effective, which likewise has been found to support immune and kidney health.

https://vitalityscience.com/product/...SABEgLKt_D_BwE
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