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Thread: Bone changes after castration in (middle-aged) rats A model for osteoporosis

  1. #1
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    Default Bone changes after castration in (middle-aged) rats A model for osteoporosis

    In middle aged male rats, neutering was not found to result in osteoporosis.

    In middle aged female rats, spaying resulted in the development of osteoporosis.

    study confirmed that middle-aged female rats on a normal diet develop osteoporosis after castration; similar findings have been made by Saville (1969) and Kalu (1983)
    Link to (summary) abstract only.

    https://pubmed.ncbi.nlm.nih.gov/3962636/

  2. #2
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    Default Re: Bone changes after castration in (middle-aged) rats A model for osteoporosis

    Quote from same study:

    Both the bone density and the calcium and hydroxyproline concentrations of the bones
    were reduced in the female (altered) castrated rats
    I.E. spaying or altering female rats promotes Metabolic Bone Disease. Save then for the calcium ratio of the diet being increased to support the high end ratio found to support bone health adult female rats, that may be enough to compensate for the lowering of calcium absorption that results from estrogen being reduced signficantly after ovariectomy or full spaying.

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