For doses used for specific conditions in rats, see notations on results under "animals" in Monograph.A monograph is a paper on a single topic. Herbal monographs normally include nomenclature, part used, constituents, range of application, contraindications, side effects, incompatibilities with other medications, dosage, use, and action of the herb.
http://abc.herbalgram.org/site/DocSe...pdf?docID=8983
When tested for toxicity, Pycnogenol was found to be very low, at 1000 mg. per 5 kg of body wt. For most conditions this source has been tested in rats the dose was 20 mg. or under. 100 mg. and 150 mg. were used orally daily for set periods of time to treat specific extreme life threatening conditions.
Used prophylactically, Pycnogenol can help prevent serious health conditions from developing.ADVERSE EFFECTS / SAFETY DATA
Preclinical Toxicology
The acute toxicity is low after oral administration in mice, rats, and guinea pigs.122 The most representative median lethal dose (LD50) value, following the current Organization for Economic Co-operation and Development (OECD) guidelines (OECD 423123), is > 5.0 g/kg body weight in rats.122
In chronic toxicity tests (OECD 408124),oral application of up to 1000 mg/kg/day in rats did not produce abnormal clinical or behavioral signs, nor any change in body weight, hematology, clinical biochemistry, or food/water consumption. Furthermore, no pathomorphological changes were found.122
The level of mutagenicity of Pycnogenol was assessed with the OECD 471125 bacterial reverse mutation test (Ames test), the micronucleus assay in mouse bone marrow cells in vivo, and the chromosome aberration assay in human lymphocytes in vitro.122 The results all converge to suggest that Pycnogenol is nonmutagenic.122 These are the published study journal, see info under Results on pg. 73.
Pycnogenol comes in various dosages, including 30, 50, 100, and 150 mg. etc.... For best absorption split dose between AM & PM feedings.
Recommended maintenance dosage for squirrels, depending on body weight, is 1/16 to 1/8 of a capsule powder daily added to a wet food.
https://www.amazon.com/Healthy-Origi.../dp/B00CLYNAUA