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Thread: Kidney Disease Info, Data, and potential treatments

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    Default Kidney Disease Info, Data, and potential treatments

    Pycnogenol

    The second important study involved patients with metabolic syndrome who were showing early signs of kidney damage (protein in urine) from high blood pressure.21 All patients were treated with ramipril (AltaceŽ), an angiotensin-converting enzyme (ACE) inhibitor drug used in hypertension, while a subgroup was supplemented with Pycnogenol as well. After six months, the Pycnogenol group experienced a number of improvements over the Ramipril-only group:
    Urinary protein fell 52.7% in supplemented subjects compared to 22.4% in the drug-only group.
    • Blood flow in the kidneys (an essential measure of kidney damage) in the Pycnogenol group improved by 139% compared to less than 100% with Ramipril alone (measured by diastolic flow).
    • C-reactive protein (an important measure of inflammation) dropped by 25.3% in Pycnogenol subjects, but decreased only slightly in the drug-only group.
    • Body mass index (BMI) was lowered in Pycnogenol subjects (5.7%), while the drug-only group did not show any significant changes after treatment.
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    L-Carnitine reverses some of the effects of kidney failure.

    https://www.ncbi.nlm.nih.gov/pubmed/15071358
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    This study has allot of info on the kidney disease in rats, with notations of blood and urine values.

    http://www.polycysticliverdisease.com/pdf/kcit2000.pdf

    Potassium citrate, and sodium Citrate are alkaline, but not as high in pH as Bi-carbonate alkaline water is. Keeping this in mind, raising urine pH that is too low, by moving it up by using these citrates, to near the exact mean urine pH of 6.5 , found for small mammals, was the goal of this research study. This to lend support to the kidneys, and greater metabolic health.

    This article here below explains how using alkalizing water should not be used for kidney failure, for it over shoots the goal of bringing up the pH of the urine to the optimum mean, raising the pH too high.

    https://medlicker.com/926-alkaline-water-dangers

    "Puts extra burden on kidneys"
    "Kidneys are body’s major excretory structures. Another important function of kidneys is to keep your body pH within normal range. For instance, when the body pH increases- becomes more alkaline- the kidneys come into action and start to excrete more bicarbonate ions into the urine. That’s how kidneys function to keep the body pH close to ideal.

    When you drink alkaline water, you’re actually making your body systems more alkaline and increasing the concentration of bicarbonate ions. At first, kidneys take on this problem and can keep the body pH normal by eliminating bicarbonate ions from body. But, once you start to rely heavily on such water, even kidneys fail to excrete all of the bicarbonate ions and this leads to metabolic alkalosis. When the body gets into alkalosis, kidneys start to function more than normal.

    That’s a bad new for all, especially for those who are already suffering from some sort of kidney disease because this will further worsen the kidney damage. If you’re suffering from kidney disease, use of alkaline water is a BIG NO for you!"

  2. #2
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    Default Re: Kidney Disease Info, Data, and potential treatments

    This is a great thread DF! Anyone with a senior squee should read through this
    Squammy to Tod

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    Default Re: Kidney Disease Info, Data, and potential treatments

    We have one of those Living Water attachments for our sink water . It can be adjusted to any pH . My husband gets stones and I swear that thing has something to do with it. Kids always pushing buttons , and he drinks whatever. I only use the regular water for the animals . Because it’s all natural well water . I figure this is the healthiest option of the two ,
    But that other thing idk. If it’s set around 7, I can drink it. Too much in either direction my stomach flips. And not trusting it for the furries.
    Awesome articles , as always DF!

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    Default Re: Kidney Disease Info, Data, and potential treatments

    Kidney damage has been associated with a high sodium diet that is associated with (hypertension) high blood pressure in rats.

    This study found that in rats given a high sugar diet that promotes diabetes, yet when restricted in sodium,

    The low-salt diet improved insulin sensitivity and prevented kidney damage.
    https://www.researchgate.net/publica...ctose-fed_rats

    It is even particularly important to support both a low sugar and low salt diet in older rats that have lowered kidney function.

    Excess sodium in the diet promotes kidney stone formation in rodents.

    Table salt is just plain toxic to the body, which no one that is concerned about their health should deliberately add to their meal, let alone that of a rodent.

    It can also cause an imbalance of potassium and sodium in the body which promotes hypertension, which is hard on the heart and the kidneys.

    https://www.ajkd.org/article/S0272-6386(85)80059-7/pdf
    Last edited by TubeDriver; 06-21-2018 at 05:15 PM.

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    Default Re: Kidney Disease Info, Data, and potential treatments

    More on high salt diet in older rats:

    https://www.news-medical.net/news/20...salt-diet.aspx

    After two weeks, all of the rats were switched to a high-salt diet for six days. In response, all of the rats showed a decrease in the level of plasma aldosterone, but the decrease was significantly less in old rats. The young rats drank and urinated more. While the old rats also drank more water, it took them longer to increase their water intake and they still drank less than the younger rats. The small increase in water did not help the old rats to produce more urine or more diluted urine, suggesting that they were not effectively clearing the excess sodium they consumed.

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    Default Re: Kidney Disease Info, Data, and potential treatments

    More on PKD and how to prevent it. If you haven't already, read about what to look for as the sign of kidney disease in rats.


    http://www.kidneyfailureweb.com/treatment/298.html More on PKD

    Polycystic kidney disease manifests in the enlargement of the kidneys from the formation of cysts, err the name, "Polycystic: 'many cysts'.

    http://www.pkdclinic.org/pkd-symptoms/1842.html

    An ammonia odor is from infection that can occur in relation to this disease.

    Bacteria split urea, separating water from ammonia, which is why you can smell the ammonia

    https://www.2ndchance.info/test.php?page=ratkidney

    Potassium Citrate was found to increase kidney function and lengthen the life of the rats with PKD.

    Citrus fruits, including oranges, grapefruits, cherries, bananas, peaches, apricots are high in both potassium and citric acid.

    Yogurt is also a good source of Potassium citrate.

    Potassium citrate is an alkalizing mineral used to counter highly acidic diet that produces urine pH below 6.0 .

    This disease still requires calcium supplementation, for calcium is lost due to this condition.

    Calcium citrate is a good form to use to support the urinary tract health of older squirrels cared for in captivity, as it is kidney friendly, not highly acidic, and not highly alkaline. Citrates in food contribute alkalinity to the diet, just not as high as Calcium carbonate does. It is a bonded form of Calcium carbonate with the organic acid Citrate that doesn't promote, but inhibits the loss of calcium in the body from oxalic acid in the diet. Unlike C. Carbonate, C. citrate is a soluble form of calcium that inhibits oxalic acid from bonding with it, which is why this form remains available for the body to use. Calcium citrate is also involved in the Krebs cycle, and plays an active part in bone formation.

    with UTI's related to calcium phosphate bladder stones from a diet too high in pH, to dissolve these stones the urine needs to be acidified.

    It is easy to get the to confused, for infections no matter how they were promoted result in alkaline urine. For this reason is crucial to determine the cause of the infection in order to do more than supply ABs in order to reverse the pH imbalance that often lies at the core of UTI. For one UTI can begin from a diet too acidic can result in Polycystic kidney disease, and promote an infection due to the dysfunction of the kidneys; but another that is from bladder stones, also promotes high pH due to an infection caused by the abrasion of calcium phosphate bladder stones, or Struvite stones that both respond to acidification of the diet.

    Keeping the diet between these two proverbial ditches pH wise is the best cure, as this supports the prevention of these conditions.

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    Default Re: Kidney Disease Info, Data, and potential treatments

    http://orthomolecular.org/resources/omns/v09n05.shtml

    "Magnesium"

    "Kidney stones and magnesium deficiency share the same list of causes, including a diet high in sugar, alcohol, oxalates, and coffee. Magnesium has an important role in the prevention of kidney stone formation.[14] Magnesium stimulates production of calcitonin, which draws calcium out of the blood and soft tissues back into the bones, preventing some forms of arthritis and kidney stones. Magnesium suppresses parathyroid hormone, preventing it from breaking down bone. Magnesium converts vitamin D into its active form so that it can assist in calcium absorption. Magnesium is required to activate an enzyme that is necessary to form new bone. Magnesium regulates active calcium transport. All these factors help place calcium where it needs to be, and not in kidney stones.

    One of magnesium's many jobs is to keep calcium in solution to prevent it from solidifying into crystals; even at times of dehydration, if there is sufficient magnesium, calcium will stay in solution. Magnesium is a pivotal treatment for kidney stones. If you don't have enough magnesium to help dissolve calcium, you will end up with various forms of calcification. This translates into stones, muscle spasms, fibrositis, fibromyalgia, and atherosclerosis (as in calcification of the arteries). Dr. George Bunce has clinically demonstrated the relationship between kidney stones and magnesium deficiency. As early as 1964, Bunce reported the benefits of administering a 420 mg dose of magnesium oxide per day to patients who had a history of frequent stone formation.[14,15] If poorly absorbed magnesium oxide works, other forms of better-absorbed magnesium will work better.

    "Magnesium citrate is a good choice: easy to find, relatively inexpensive and well absorbed."
    In laboratory research, studies were done to determine factors that prevented the formation of kidney stones in rats. In one study, a close ratio of (Ca:P) and (Ca:Mg) (1.60 : 1), was found to prevent kidney stones from forming in the rats.

    In diets for tree squirrels, testing for magnesium bowel tolerance can easily be done, as. Dr. Carolyn Dean, M.D. and N.A. an expert in magnesium in the diet, describes this in her written works. Basically, this is raising magnesium supplementation up till the stool becomes lose, then backing down to where till it firms up.

    I use this source of Magnesium Citrate.

    https://www.amazon.com/Frontier-Magn.../dp/B000UYC3MY for this purpose.

    Since not all supplements measure out to the same mg. amounts, these measures here only apply to using this source.

    With a block diet, add (1/64 Tsp.) in addition every couple days till the stool becomes noodle like; then back down by the same measure to bring stool back to normal pellets, allowing the body a chance to adjust to the increase magnesium, which is normal. Should diarrhea result from the last increase then lower it down (1/64 Tsp.) immediately to where it reaches noodle form and wait a couple of days to see if it firms up again. If not then lower it again by the same measure.

    With the support of a lower anti-nutrient (lower oxalate) (lower goitrogen), and lower fat diet for tree squirrels in captivity, that has a mean urine pH of (6.5), a (6.4-6.6) spread, the mean that has been found for small mammals, and a whole diet ratio of (2:1) for (Ca:P), and a close ratio of (Ca:Mg), long term urinary and metabolic health can be well supported.

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    Default Re: Kidney Disease Info, Data, and potential treatments

    There is another important fact in regard to kidney stone formation in rats; kidney stones more commonly form in the females.

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    Default Re: Kidney Disease Info, Data, and potential treatments

    Overview of symptoms, types, causes, and diagnosis of kidney stones in rats:

    http://www.petmd.com/exotic/conditio...t_urolithiasis

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    Default Re: Kidney Disease Info, Data, and potential treatments

    Include calcium supplements with meals:

    "since taking them in-between meals may actually increase the risk of stone formation".
    Calcium carbonate supports binding up of soluble oxalate (oxalic acid) into the insoluble form of Calcium oxalate in the intestinal tract. Research has confirmed that in most humans very little CaOx is absorbed into the bloodstream, as most of it is lost out the bowel; yet in rats it is noted that though much CaOx is lost out the bowel, allot is absorbed into the bloodstream.

    Calcium citrate supports the kidneys to excrete urinary citrate, which inhibits calcium from bonding with oxalic acid that forms insoluble Calcium oxalate (CaOx); for once free calcium bonds with citrate it then cannot bond with oxalic acid. This is why the citrate form preserves more calcium for the body to use, while inhibiting the formation of (CaOx) stones in the kidneys. For these reasons, a healthy diet that promotes a mean urine pH in the slightly acidic range of (6.4 - 6.9), which is supplemented with Calcium citrate, lends more support to both urinary tract and metabolic bone health in adult rodents.

    A study comparing rats to humans in regards to oxalate absorption:

    "concluded that a higher proportion of dietary oxalate is absorbed in the rat intestine compared with man, and that dietary oxalate accounts for a higher proportion of urinary oxalate in the rat than in man. Intestinal secretion and bacterial degradation of oxalate also appear to be proportionately greater in the rat than in man."
    Last edited by TubeDriver; 09-17-2018 at 01:16 PM.

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    Default Re: Kidney Disease Info, Data, and potential treatments

    https://www.ncbi.nlm.nih.gov/pmc/art...00543-0407.pdf

    In this first study done on reducing the incidence of kidney stones (nephrocalcinosis) in rats, the two test groups were fed different diets: a calcium deficient diet that provided: (0.7% Ca , 0.8% P, and 0.2 % Mg), along with a supplement of magnesum chloride added to the drinking water; and a calcium enriched diet that provided: (1.4 % , 0.8% P, 0.2% Mg). The results were as follows:

    Of the two methods used to test whether they would prevent kidney stones from forming, “The inclusion of magnesium (chloride) in the drinking water completely prevented the formation of crystals; the use of the calcium-enriched diet significantly reduced the incidence of the lesion (crystals), but did not completely prevent it. Both methods, however, resulted in normal growth curves for the treated animals.
    http://www.sciencedirect.com/science...22534717394661

    In this study, each of the test groups of rats were fed a diet with a compound that produces a highly acidic calcium oxalate kidney stone provoking diet, not to be confused with a low oxalate slightly acidic diet, that supports a healthy range for urine pH in rats. Of the five test diet groups, a different form of magnesium, with an otherwise identical standard diet was included. The results were as follows: Three forms of magnesium, including Magnesium Citrate, were found to prevent the formation of CaOx urinary calculi in the rats. The other two forms, Magnesium sulfate and Magnesium oxide, failed to prevent the formation of urinary calculi, the precursor to Calcium Oxalate kidney stone formation.

    Abstract

    Magnesium oxide, magnesium hydroxide, magnesium sulfate, magnesium trisilicate, and magnesium citrate were added to a calcium-oxalate lithogenic diet in order to determine their effects in preventing lithogenesis. Male Wistar-strain rats which had been fed the glycolic-acid diet developed marked urinary calculi within four weeks. Rats in the magnesium-hydroxide, magnesium-citrate, and magnesium-trisilicate groups, however, had almost no stones in the urinary system. Rats in the magnesium-oxide and magnesium-sulfate groups showed significantly less effect than those in the former three groups.
    In this study in magnesium to prevent kidney stones in rats, Magnesium Citrate prevented stone formation.

    Magnesium oxide, the most common default form of magnesium included n rodent block diets, and Magnesium carbonate, that are noted to have had a significantly less effect, did not prevent kidney stone formation in rats.
    Last edited by TubeDriver; 03-23-2019 at 05:01 PM.

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